Isolation and structural elucidation of stipiamide, a new antibiotic effective to multidrug-resistant cancer cells.
نویسندگان
چکیده
منابع مشابه
Isolation and structural elucidation of stipiamide, a new antibiotic effective to multidrug-resistant cancer cells.
Sir: Resistant of tumor cells to multiple cytotoxic drugs is a major impediment to cancer chemotherapy. Multidrug-resistance (MDR) is characterized by decreased cellular sensitivity to anticancer agents due to the increased expression of a membrane glycoprotein with a MWof approximately 170 kd, termed P-glycoprotein1}. It is well known that colchicine-resistance cells have simultaneously acquir...
متن کاملISOLATION AND STRUCTURAL ELUCIDATION OF THE FIRST KNOWN C-HOMOPROTOBERBERINE
A novel C-homoprotoberberine alkaloid, Hediamine (2), has been isolated from the roots of Berberis actinucantha (Berberidaceae). Conclusive proof for the structure of hediamine was obtained by its comparison with the isomeric lactam (4), by chemical transformation, and by means of spectroscopic techniques (UV, IR, MS, NMR).
متن کاملEvaluation of Antibiotic Resistance to Colistin in Nosocomial Infections with Multidrug-Resistant Acinetobacter
Background and Objective:Acinetobacter infection is one of the most common nosocomial infections that its antibiotic resistance has increased in recent years.This study aimed to evaluate drug resistance to colistin in nosocomial infections with multidrug-resistant (MDR) Acinetobacterbaumannii. Materials and Methods:This cross-sectional study was performed on 45 blood or body fluid culture samp...
متن کاملIsolation and structure elucidation of a new alkaloid from the Indonesian Blue-Green Alga Arthrospira platensis
A new alkaloid (1) and two known compounds (2 and 3) were isolated from the blue-greenalga Arthrospira platensis. Their structures were determined on the basis of spectroscopic data.According to the obtained data and values in the literature, the compounds were concluded to beeckol.
متن کاملSeitomycin: isolation, structure elucidation and biological activity of a new angucycline antibiotic from a terrestrial Streptomycete.
A new antibiotic, named seitomycin (1c), and the known microbial metabolite tetrangulol methyl ether (2) were found in the ethyl acetate extract of two terrestrial Streptomyces sp. isolates. The structure of the new antibiotic was elucidated by spectroscopic studies and by comparison of the NMR data with the structurally related hatomarubigin C (1a) and SM-196 B (1b). Seitomycin (1c) showed mod...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1991
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.44.553